So, should you choose Acuna Jr. or Rodriguez (3/26/26)?
Batter vs pitcher
Acuna Jr. has a day off, be sure to start Rodriguez.
Weather impact
Heavy wind (blowing out), hot temps, ballpark elevation, etc can all have a big impact on long fly balls. An extra few feet can be the difference between warning track and a 3-run dinger. Acuna Jr. has a day off, no weather stress. Meanwhile, Rodriguez will be playing under an HRForce of n/a [dome (and likely closed)].
Weekly Roster Lock Leagues
For those of you in leagues that require you to set your lineup before the start of each week, off-days can be a bummer. Everything else being equal, give the edge to guys that play at least one more game a week. For the Mon-Sun week that includes 3/26/26, Acuna Jr. has 3 games scheduled, while Rodriguez has 4. So, with one more game, that could make a difference, especially in H2H leagues where you need to pile up points. Slight advantage to Rodriguez.